Orthomolecular medicine: basics, effects, applications

Orthomolecular medicine exclusively uses these substances that are endogenous or derived from food and aims to compensate for deficits and restore the biochemical balance in the body. In layman’s terms: Our cells should receive all the building blocks in the optimal amount that they need to remain healthy and efficient.

Great importance is attached to a scientifically sound basis. Numerous vital substances are essential – the human body needs over 100 different micronutrients for all organs to function healthily.

If these substances are missing, a variety of problems can arise. Orthomolecular medicine starts right here: Micronutrients are used as therapeutics, sometimes in high doses, to compensate for deficiencies and support the self-healing powers.

However, it is important that this is done on an individual basis, as each person has their own requirements, depending on their diet, age, state of health and even genetic factors.

In this article you will get a comprehensive overview of the basics of orthomolecular medicine, the role of important nutrients, their significance for the immune system, cell protection, energy, anti-inflammation and hormone balance, as well as the diverse areas of application – from anti-ageing to support for chronic fatigue.

You will also find out why an individual vital substance analysis (e.g. through blood and genetic analysis) is so important and how the provider VenaZiel puts this natural approach into practice with modern diagnostics (incl. MRI and genetic analysis) and personalized advice.

 

Vitamins, minerals, trace elements & co.: the building blocks of orthomolecular medicine

Micronutrients are the central players in orthomolecular medicine. These include primarily vitamins and minerals, but also trace elements, amino acids, essential fatty acids, and secondary plant substances such as antioxidants.

In contrast to macronutrients (carbohydrates, protein, fat), which provide the body with energy, micronutrients are involved in the countless biochemical processes in the body – often as cofactors of enzymes or as structural components of cells and hormones. Here is an overview of the most important micronutrient groups and their role:

• Vitamins – vital all-rounders: Vitamins are organic compounds that the body needs for numerous functions. A distinction is made between fat-soluble vitamins (A, D, E, K) and water-soluble vitamins (C and the B vitamins). They are involved in growth, the immune system, metabolism, the nervous system, and many other processes.
  Some examples: Vitamin A supports vision and the immune system (it used to be called the “anti-infectious vitamin” due to its importance for defense), vitamin C acts as an important antioxidant and strengthens the immune system, the B vitamins (B1, B2, B3, B5, B6, B7/biotin, B9/folic acid, B12) play central roles in energy metabolism, blood formation, and nerve function. Since vitamins, with the exception of vitamin D, cannot be produced by the body itself, they must be supplied regularly through food (or supplements). 
• Minerals and trace elements – small amounts, big effect: Minerals (such as calcium, magnesium, potassium) and trace elements (such as iron, zinc, selenium, copper, iodine) are inorganic nutrients that are essential for the body. Minerals are needed in somewhat larger quantities – e.g. calcium for bones and teeth, magnesium for muscle function and the heart and as an anti-stress mineral.
  Trace elements are only needed in tiny amounts, but are nevertheless critical: iron is needed for the formation of red blood cells and oxygen transport, zinc controls hundreds of enzyme reactions and supports wound healing as well as the immune system and hormone production, selenium is part of important antioxidant enzymes and is essential for thyroid function.
  An imbalance – whether deficiency or excess – can have significant effects on health. Orthomolecular medicine, therefore, focuses on keeping these micronutrients in the optimal range. 
• Amino acids – building blocks of proteins and more: Amino acids are the basic building blocks of proteins. Some amino acids are essential, i.e. they must be taken in with food (e.g. leucine, lysine, tryptophan), others can be produced by the body itself.
  In addition to their function as protein components, many amino acids have specific effects: Tryptophan is a precursor of the happiness hormone serotonin and can therefore influence mood and sleep, glutamine serves the cells of the intestine and immune system as a preferred source of energy, arginine promotes blood circulation (precursor of nitric oxide) and supports immune function, glycine is involved in detoxification.
  Amino acids are also used specifically in orthomolecular therapy, for example to support brain metabolism or the muscles if there are corresponding deficits or increased requirements.
  Protein enzymes such as coenzyme Q10 – strictly speaking a vitaminoid – or carnitine (transport molecule for fatty acids into the mitochondria) also fall into this extended area of vital substances, as they are important for cell energy and metabolism. 
• Antioxidants – cell protection against free radicals: Antioxidants are substances that can reduce oxidative stress by neutralizing harmful free radicals.
  Many vitamins and trace elements act as antioxidants: e.g. vitamin C in aqueous areas of the body (blood, cell plasma) and vitamin E in fatty structures such as cell membranes.
  Selenium and zinc are components of antioxidant enzyme systems (such as glutathione peroxidase and superoxide dismutase). Secondary plant substances (polyphenols, carotenoids such as beta-carotene, flavonoids) are also included. Antioxidants protect cells from aging processes and environmental pollution and, therefore, play an important role in the prevention of diseases and in anti-aging. More on this in the Cell Protection section below.

Tip: A balanced diet with plenty of fresh fruit, vegetables, nuts, whole grains, and fish provides an abundance of these micronutrients. Orthomolecular medicine also relies on specifically increasing the supply in the event of specific additional needs or illnesses.

In the next step, we will look at how exactly these vital substances work in the body – especially in relation to the immune system, cell health, energy, inflammatory processes, and the hormone system. These areas of action illustrate why orthomolecular medicine is relevant to many aspects of health.

 

Immune system: vitamins and minerals as a protective shield

A well-functioning immune system depends largely on an adequate supply of micronutrients. In fact, there is hardly a nutrient that does not play some role in the immune system. Various vitamins and minerals act as fuel and regulators of our defense system: They support the formation and activity of immune cells, the production of antibodies, and communication via messenger substances (cytokines).

Particularly important for the immune system are vitamin C, vitamin D, vitamin A, the B vitamins (B6, B12, folate) as well as zinc, selenium, iron, and copper. All of these micronutrients contribute to the normal function of the immune system.

Vitamin A, for example, is also known as an “anti-infectious vitamin” due to its protective effect on the skin and mucous membranes – our first barrier against germs. Vitamin D acts as an important immune-regulating molecule: It supports the maturation of immune cells and inhibits excessive inflammatory reactions, which is relevant, for example, in autoimmune diseases. According to studies, an adequate vitamin D level reduces susceptibility to respiratory infections and can alleviate the course and severity of infections.

Vitamin C is essential for the function of white blood cells; in the event of infections, the body’s consumption of this vitamin increases sharply. It has been shown that vitamin C can weaken and shorten cold symptoms. Vitamin C also promotes the breakdown of histamine, a substance that plays a role in allergies, and can, therefore, alleviate allergic reactions.

B vitamins are also immunologically relevant: B6, B12, and folate are needed for the formation and reproduction of immune cells; a deficiency can impair antibody production and inflammatory defense. Zinc is a trace element that supports almost all components of the immune system – from the skin barrier to the production of lymphocytes.

A zinc deficiency often leads to increased susceptibility to infection and poor wound healing. Selenium protects immune cells from oxidative damage and is important for inflammation regulation. Iron, in turn, is needed by immune cells for their division; at the same time, a good iron metabolism deprives pathogens of this element, which is also important for them.

For a strong immune system, it, therefore, makes sense to pay attention to an all-round adequate supply of micronutrients. In orthomolecular medicine, the individual status of these nutrients is often checked using a blood test in order to specifically replenish what is missing.

This can be particularly useful for people with frequent infections, immune deficiencies, allergies, or autoimmune diseases. Important: Targeted supplementation after diagnosis helps to supplement exactly those vital substances that are actually needed – this optimally supports the immune system without unnecessarily burdening the body.

 

Cell protection: antioxidants against free radicals

Our cells are attacked daily by so-called free radicals – aggressive oxygen compounds that are produced, for example, during normal metabolism, stress, smoking, UV radiation or environmental pollution.

If these radicals get out of hand, oxidative stress occurs, which can damage cells and promote aging processes and chronic diseases. Antioxidants are nature’s answer to this problem. They render free radicals harmless and thus protect cells, proteins, lipids, and even DNA from damage.

Important antioxidants in the body are vitamin C, vitamin E, beta-carotene/vitamin A, as well as the trace elements zinc, selenium, and copper, which are components of antioxidant enzymes. Vitamin C works as a radical scavenger in the aqueous environment of the cell and in the blood – it catches, for example, radicals before they can damage the cell membrane or other structures.

Vitamin E sits directly in the cell membranes and protects the fat layers from oxidation. A vitamin E deficiency is associated with increased susceptibility to infection and a tendency to inflammation, while a good vitamin E supply has been shown to reduce the frequency of respiratory infections, for example, in older people.

Beta-carotene (provitamin A) and other carotenoids such as lutein and lycopene protect sensitive tissues (e.g. the eyes or skin) from UV damage and oxidative stress. Selenium is essential for the enzyme glutathione peroxidase, which protects cell membranes from peroxide formation, and zinc and copper are part of superoxide dismutase, an enzyme that neutralizes dangerous superoxide radicals.

Antioxidants such as those found in fresh berries (rich in vitamin C and polyphenols) act as natural radical scavengers that protect cells from oxidative stress and counteract aging processes. In addition to the vitamins and minerals mentioned, secondary plant substances also provide strong cell protection.

For example, berries, green tea, cocoa, turmeric, red grapes, etc. are considered rich in polyphenols and flavonoids, which have an antioxidant and anti-inflammatory effect. This cell protection through antioxidants is not only important for anti-aging (healthy skin, tissue protection, prevention of premature aging), but also plays a role in the prevention of chronic diseases such as cardiovascular diseases, some types of cancer, and neurodegenerative diseases.

Studies show, for example, that people with a higher intake of antioxidants have a lower risk of certain chronic diseases – although it must always be emphasized: Antioxidants are prevention aids, not miracle cures.

A well-balanced network of antioxidants in the body (including endogenous substances such as glutathione, coenzyme Q10 and enzymes) ensures that free radicals are kept in check.

In orthomolecular medicine, antioxidants are often used in high doses to counteract increased oxidative stress – for example, high doses of vitamin C (sometimes as an infusion) to support the immune system or vitamin E for inflammatory diseases.

The right dosage and combination are always important: Too much of a single antioxidant can, under certain circumstances, also have a pro-oxidative effect if it is overdosed in isolation. Therefore, it is better to rely on a mix of different antioxidants, adapted to individual needs, to ensure optimal cell protection.

 

Energy production: micronutrients for more energy and performance

Do you often feel tired or exhausted? Then it might be worth taking a look at the micronutrients, because our energy production in the cells – mainly in the mitochondria, the “power plants” of the cells – depends largely on vitamins and minerals.

The conversion of food into ATP (adenosine triphosphate), the universal energy carrier, requires a whole range of cofactors. B vitamins play a central role here: All B vitamins except folic acid are indispensable in at least one, usually several, steps of cellular energy production.

For example, vitamin B1 (thiamine) is needed for the breakdown of carbohydrates and entry into the citrate cycle – a B1 deficiency quickly leads to fatigue and difficulty concentrating. Vitamin B2 (riboflavin) and B3 (niacin) are components of the coenzymes FAD and NAD, which transport electrons in the respiratory chain of the mitochondria and thus enable ATP production.

Vitamin B5 (pantothenic acid) is a component of coenzyme A, also essential in energy metabolism, and the body needs vitamin B6 to convert amino acids for energy production. Vitamin B12 and folic acid, in turn, are important for blood formation (oxygen transport) and for the nerves – a deficiency manifests itself, among other things, in fatigue, weakness, and neurological disorders.

In addition to the B vitamins, minerals such as magnesium and iron are crucial: Magnesium is involved in hundreds of enzymatic reactions and is essential for the stabilization and use of ATP. Iron is needed for oxygen transport with the blood (via hemoglobin) and is also used by the mitochondria for energy production.

An iron deficiency can, therefore, lead to a lack of energy and reduced performance (e.g. in anemia). Zinc and selenium indirectly support the energy supply, among other things, through their role in thyroid functions (the thyroid hormones regulate the basal metabolic rate) and in protecting the mitochondria from oxidative stress.

Coenzymes and other vital substances are particularly exciting: For example, coenzyme Q10 is a central building block of the mitochondrial respiratory chain – it acts as an electron transporter. A deficiency of Q10 (which can occur with increasing age or through taking certain medications such as statins) is associated with muscle weakness and fatigue.

Carnitine is important for transporting fatty acids into the mitochondria, where they are burned; without sufficient carnitine, fat remains unused as an energy reserve. Lipoic acid, a vitamin-like substance, also plays a role in energy metabolism and at the same time has an antioxidant effect in the mitochondria.

One recognizes: No energy without micronutrients. Anyone who suffers from exhaustion in the long term should not only think about sleep and stress, but also about their supply of vital substances. Chronic fatigue can be caused, for example, by deficits in B12, B1, B6, iron, vitamin D, or magnesium.

Under persistent stress, the consumption of these vital substances even increases, which can lead to a vicious cycle. An optimal supply, on the other hand, allows the “energy power plants” to work efficiently. A health platform recommends: “To produce enough energy, the mitochondria need vitamin B1, B2, B3, B5, and B6 as well as trace elements such as iron, zinc, and selenium – as well as coenzymes such as Q10.”

Exactly these substances are used in orthomolecular medicine to improve cellular energy production. In many cases, patients with chronic fatigue or burnout report that an individually tailored micronutrient therapy has been able to significantly increase their energy and performance. (More on this later in the areas of application.)

In summary: Micronutrients are the spark plugs in the engine of our metabolism. From the food chain to ATP synthesis – nothing works without vitamins and co. Orthomolecular medicine ensures that all these little helpers are available in sufficient quantities so that we feel vital and energized.

 

Inflammation inhibition: nutrients as natural inflammation modulators

Chronic inflammation is considered a smouldering danger in the body – it is associated with numerous diseases of civilization (from joint problems and cardiovascular disorders to diabetes and neurodegenerative diseases).

Interestingly, many micronutrients can have anti-inflammatory effects by interfering with the immune response and the production of inflammatory messengers.

A prominent example is vitamin D: This “sun vitamin” regulates the release of cytokines (messenger substances of the immune system) and can dampen excessive inflammatory reactions. Studies have shown that patients with sufficient vitamin D levels often have milder courses of inflammatory diseases than those with vitamin D deficiency. Vitamin D can also help to bring the immune reaction back into balance in autoimmune diseases (where the immune system is overactive and “misdirected”).

Vitamin E not only acts as an antioxidant but also directly anti-inflammatory by, for example, inhibiting the release of pro-inflammatory molecules. Vitamin E has been successfully used as an accompanying measure for arthritis, allergies, and skin inflammations to alleviate the symptoms.

In addition, omega-3 fatty acids (EPA and DHA, e.g. from fish oil or algae oil) play a major role in inhibiting inflammation. They compete with omega-6 fatty acids in the body and lead to the formation of more inflammation-resolving rather than inflammation-promoting eicosanoids (tissue hormones).

Numerous studies prove that omega-3 supplementation can lower chronic inflammatory markers and alleviate joint discomfort, e.g. in rheumatism. In orthomolecular medicine, omega-3 fatty acids are often given together with antioxidants because inflammation and oxidative stress go hand in hand.

Herbal anti-inflammatories are also part of the repertoire: curcumin (from turmeric), resveratrol (from red grapes), ginger extracts or boswellic acids (frankincense) are natural substances with a strong anti-inflammatory effect that can be used as orthomolecular supplements.

Although these are not “classic” vitamins or minerals, they are among the vital substances that orthomolecular medicine values to support the body in regulating inflammation.

Last but not least, magnesium should be mentioned: As an anti-stress mineral, it helps to calm the nervous system and regulate the stress hormone axis. Prolonged stress is known to lead to increased release of cortisol, which in high doses has an immunosuppressive and bone-degrading effect and tends to promote inflammation.

Magnesium can mitigate this stress-inflammation spiral, among other things by limiting histamine release (so allergic inflammatory reactions are dampened). The body also needs enough zinc and vitamin C to resolve inflammatory processes and repair tissue.

Overall, it can be said that micronutrients work in secret as small anti-inflammatories. They strengthen the body’s own mechanisms to limit inflammation and regenerate damaged tissue.

Therefore, orthomolecular medicine – especially in the case of chronic inflammatory diseases such as arthritis, intestinal inflammation, skin eczema, or even silent inflammation (e.g. in metabolic syndrome) – relies specifically on these natural helpers. The advantage is that vitamins, minerals, and co. in contrast to drugs are physiological substances and usually have fewer side effects, but at the same time address the causes (namely, compensate for nutrient imbalances and restore normal immune control).

Of course, this should be done alongside and in consultation with therapists, especially in the case of serious illnesses, but experience shows that orthomolecular strategies can have a beneficial effect on inflammatory processes.

 

Hormone balance: micronutrients as silent helpers of the hormone system

Our hormone system is a finely tuned network of messenger substances that regulates numerous functions – from metabolism to growth to mood and reproduction. The fact that micronutrients are also required for the formation and function of hormones is easily overlooked. In fact, vitamins and minerals are integral components of many hormones or the enzymes that produce and activate hormones.

A classic example is the thyroid gland: Iodine is needed to produce the thyroid hormones T3 and T4 – an iodine deficiency can lead to thyroid underfunction (hypothyroidism). At the same time, the thyroid gland needs selenium, as important enzymes (deiodases) are selenium-dependent in order to convert the storage hormone T4 into the active T3. Without sufficient selenium and iodine, the thyroid hormone balance gets out of balance, which can manifest itself in a lack of energy, weight gain, or sensitivity to cold.

Vitamin D itself is actually more of a hormone than a vitamin – in addition to calcium balance, it also regulates many gene-regulatory processes and influences, for example, the insulin release of the pancreas and the testosterone level. An optimal vitamin D status is associated with a balanced hormone balance and better fertility, while a deficiency can derail the stress hormone cortisol, for example.

Micronutrients also play a role in sex hormones: Zinc is important for the formation of testosterone and influences the receptor sensitivity of estrogen. A zinc deficiency can therefore be associated with low testosterone or erectile dysfunction, while adequate zinc intake improves fertility (sperm quality) in men.

Vitamin B6 is a cofactor in the synthesis of various neurotransmitters and hormones – for example, it helps in the formation of serotonin and dopamine, which indirectly influence the hormone balance (e.g. stress and sex hormones). B6 also contributes to the regulation of estrogen, which is why it is used in natural PMS therapy.

Pantothenic acid (vitamin B5) is necessary for the production of steroid hormones such as cortisol, testosterone and estrogen – it forms part of coenzyme A, which is involved in the synthesis of these hormones.

Not to forget magnesium and vitamin C: Both are needed by the adrenal glands to produce stress hormones (adrenaline, noradrenaline) and break them down again at the same time. In the case of chronic stress, “adrenal fatigue” can occur, in which magnesium and vitamin C levels are often depleted.

The influence of amino acids is also interesting: serotonin (happiness hormone) is produced from the amino acid tryptophan and from this melatonin (sleep hormone) – this process in turn requires micronutrients such as B6, B3, zinc and magnesium as cofactors.

The thyroid hormones and the adrenal hormones adrenaline and noradrenaline are formed from phenylalanine/tyrosine; several vitamins are also involved here. It can be seen that hormone production is like a complicated assembly line in which vitamins (especially B vitamins), minerals and amino acids are involved as cogs.

For a balanced hormone balance it is therefore not only important to eat enough calories, but also the quality of the nutrient intake.

In orthomolecular medicine, in the case of hormonal complaints – be they thyroid problems, stress hormone imbalances (burnout/adrenal fatigue), fertility disorders or menopausal symptoms – one can provide supportive intervention by specifically administering those vital substances that the hormone system lacks. For example, an individually tailored administration of iodine, selenium, zinc and vitamins can help the thyroid metabolism, or magnesium and B vitamins can normalize cortisol regulation in the event of stress-related exhaustion.

Studies and experience show that patients are often less susceptible to stress and hormonal fluctuations after orthomolecular support and benefit, for example, from sleep, energy and mood.

In summary: Micronutrients are the secret helpers of the hormone system. They ensure that hormones are formed, activated, regulated and broken down correctly. An individual vital substance analysis (see next section) can provide information as to whether there are deficits here that should be compensated for – for a harmonious “hormone balance” in a natural way.

 

Areas of application of orthomolecular medicine: from anti-ageing to chronic diseases

Orthomolecular medicine is used in many areas, be it preventatively for health care or therapeutically as an accompaniment to a wide range of complaints. Here are some of the most important areas of application and examples of how micronutrients can help:

• Anti-aging and prevention: One of the major trends is the use of vital substances in anti-aging. Antioxidant vitamins (C, E, beta-carotene), coenzyme Q10, omega-3 fatty acids and trace elements such as selenium or zinc are intended to slow down the aging process at the cellular level by reducing oxidative stress and preventing inflammation. This manifests itself, for example, in healthier skin (collagen formation through vitamin C, skin protection through vitamin E), better immune function in old age and protection against degenerative processes.
  Prevention in general – i.e. the prevention of diseases – is also a core concern: Micronutrients can help to minimize risk factors (such as B vitamins plus omega-3 to lower homocysteine levels and inflammation markers, which reduces cardiovascular risks).
  Important to emphasize: Orthomolecular medicine is not a fountain of youth pill, but a building block of a health-conscious lifestyle that can promote a high level of vitality into old age.
  Those who consciously replenish their micronutrient stores from around 40+ can often observe that typical age-related complaints (tiredness, lack of concentration, susceptibility to infections) are reduced.
• Chronic exhaustion and burnout: Orthomolecular therapy has proven to be very helpful in the case of constant fatigue, burnout or Chronic Fatigue Syndrome (CFS). Under constant stress, the depot of B vitamins, magnesium, vitamin C and other vital substances empties rapidly.
  At the same time, stress can disrupt the digestion and absorption of nutrients. The result is a vicious circle of exhaustion and vital substance deficiencies. Here, highly dosed B vitamins (B complex), magnesium and, if necessary, adaptogens (such as rhodiola or ashwagandha, which mitigate stress reactions) are used, among other things.
  Studies report that targeted micronutrient therapy based on laboratory results can sustainably improve burnout syndrome. In particular, energy production in the mitochondria is promoted (e.g. by coenzyme Q10, acetyl-L-carnitine, nicotinamide riboside, etc.), which often leads to a noticeable improvement in performance in the case of chronic fatigue.
  Patients with burnout often feel more resilient again more quickly under orthomolecular support, sleep better and are better able to compensate for stress again. What is important here is individual diagnostics (see below) in order to determine which vital substances are lacking in the specific case – be it vitamin D in winter, iron in women with exhaustion, or B12 in vegans. 
• Cardiovascular health: The health of the heart and blood vessels can be positively influenced by micronutrients. For example, omega-3 demonstrably helps to lower triglyceride levels, has a blood pressure-regulating and anti-inflammatory effect – good for the heart and circulation.
  Magnesium relaxes the vascular muscles, can prevent cardiac arrhythmias and moderately lower blood pressure. Coenzyme Q10 improves the energy supply to the heart muscle and is used as a supportive measure in the case of heart failure (also because Q10 is reduced by statins).
  Another topic is homocysteine: elevated homocysteine levels in the blood are considered a risk factor for arteriosclerosis. Homocysteine can be broken down by an adequate supply of vitamin B6, B12 and folic acid – orthomolecular medicine uses this for the prevention of heart attack and stroke. Antioxidants (vitamin C, E, selenium) also protect the inner walls of the vessels from oxidative damage (e.g. from oxidized LDL cholesterol).
  All in all, a personalized supply of vital substances can help to keep high blood pressure, high blood lipids or vascular calcification in check – of course always in combination with lifestyle measures such as a healthy diet, exercise and stopping smoking. 
• Gastrointestinal tract and digestion: Digestive problems, irritable bowel syndrome, chronic inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) or simply damaged intestinal flora can impair nutrient absorption. Here, it is first important to compensate for deficiencies as a result of poor absorption (such as B12 in the case of absorption disorders in the small intestine, or iron/zinc in the case of chronic inflammation).
  Orthomolecular medicine also supports intestinal health itself: Glutamine, for example, is an amino acid that can regenerate and seal the intestinal mucosa (keyword: leaky gut prevention).
  Omega-3 fatty acids and vitamin D have an anti-inflammatory effect in the intestine in IBD (inflammatory bowel disease). Probiotics and prebiotic fiber (although not micronutrients in the classical sense, but nevertheless important components of food) are also often combined with orthomolecular concepts in order to improve the intestinal environment.
  In addition, digestive enzymes, bitters or magnesium (against constipation) can be used. Last but not least: The intestinal immune system (70% of the immune cells are located in the intestine) benefits from zinc and vitamin A, which keep the mucous membranes intact. In this way, orthomolecular therapy helps, for example, irritable bowel syndrome patients to restore balance, close nutrient gaps and soothe inflammation – often with the effect that abdominal pain, bloating or intolerances are reduced. 
• Skin, hair and connective tissue: The skin, as the largest organ, reacts very sensitively to nutrient supply. Many skin problems can be improved by orthomolecular measures. Acne, for example, is often associated with zinc deficiency – zinc reduces sebum production and inflammation in the skin.
  Biotin (vitamin B7) and vitamin B2 are important for a healthy skin barrier; their deficiencies can lead to flaky skin or cracks. Vitamin C, collagen peptides, silicon, sulfur (MSM) strengthen the connective tissue and can slow down cellulite or wrinkle formation by promoting collagen synthesis. Antioxidants protect the skin from UV damage and aging – beta-carotene, for example, acts like an internal sunscreen to a certain extent.
  Hair loss and brittle nails are other areas: Here, biotin, zinc, selenium, iron and amino acids such as cysteine often come into play, which strengthen the keratin structure. In the case of skin eczema or neurodermatitis, supplementation with omega-3, vitamin D and probiotics has proven helpful in studies in order to reduce the skin’s susceptibility to inflammation.
  Orthomolecular medicine therefore also offers approaches in the area of beauty and healthy appearance that work from within – without any chemicals, but with nutrients that make the skin glow and strengthen the hair. 
• Neurological complaints and mental health: The brain and nerves are dependent on micronutrients. In the case of neurological diseases such as polyneuropathies (nerve damage), for example, a vitamin B12 deficiency or B1 deficiency is often found – supplementation can improve numbness and nerve function disorders.
  Magnesium and vitamin B2 can reduce migraine attacks, as they are involved in neuromuscular excitation and energy supply to the brain cells. Vitamin D plays a role in neurodegenerative diseases: Deficiency may increase the risk of multiple sclerosis or Parkinson’s disease, while good supply could slow down the progression (research on this is still ongoing).
  In the area of mental health, we know the classic correlations: low folic acid and B12 levels can contribute to depression (homocysteine increases, serotonin production decreases), an omega-3 deficiency is associated with an increased risk of depression and anxiety, magnesium has a calming effect on anxiety and sleep disorders.
  Orthomolecular approaches therefore provide, for example, in the case of depression, an accompanying administration of highly dosed B vitamins, magnesium, omega-3 and amino acids (such as tryptophan or tyrosine) in order to optimize the biochemical environment in the brain. Dementia prevention is also a topic: Antioxidants such as vitamin E and C, omega-3 and B vitamins are being investigated to see whether they can slow down cognitive decline.
  While orthomolecular medicine cannot of course cure neurological diseases, it can provide a building block to optimally nourish the nerves and brain and thus alleviate symptoms or delay their progression.

To summarize: orthomolecular medicine is used in almost all areas where something is “missing” or out of balance in the body.
It serves prevention by creating optimal conditions for health, and support for therapies by giving the body the resources it needs to help itself better. It is always important to personalize the measures – which leads us to the next point: individual diagnostics.

 

Individual vital substance analysis: Why diagnostics are so important

Every person has a unique nutrient requirement and status. What one lacks, the other has in abundance. Therefore, orthomolecular medicine attaches great importance to individual diagnostics before micronutrients are specifically recommended or supplemented. An individual vital substance analysis can include several building blocks:

• Blood tests: The gold standard is a comprehensive blood test to determine the status of various vitamins, minerals, trace elements and markers. This includes, for example, the measurement of 25-OH-vitamin D (storage form of vitamin D in the blood), vitamin B12 and holotranscobalamin (active B12), folic acid, iron/ferritin, magnesium, zinc, selenium, vitamin A, vitamin E, hs-CRP (inflammation marker), homocysteine (as an indication of B vitamin deficiency) and many more.
  An amino acid profile in the blood or urine can also be created to see whether, for example, tryptophan, glutamine or other important amino acids are sufficiently available. This comprehensive micronutrient diagnostics shows which nutrients are actually lacking instead of supplementing blindly.
  Example: Fatigue can be caused by iron deficiency, B12 deficiency, vitamin D deficiency or an excess of calcium (which displaces magnesium) – the blood values provide clarity. 
• Genetic tests (gene analysis): Genetics influences how we metabolize nutrients. There are now nutrigenetic tests that, for example, examine whether you have genetic variants that influence the absorption or processing of certain vitamins.
  The MTHFR polymorphism, which makes folic acid utilization more difficult, is well known – people with this gene variant often need activated folate (5-MTHF) instead of normal folic acid. Other tests look at lactose intolerance genes, gluten intolerance markers or also genes that determine the detoxification capacity (glutathione system).
  A genetic analysis can show where congenital weaknesses lie so that targeted countermeasures can be taken – for example by increasing the intake of certain vitamins or using special forms (e.g. methyl-B12 instead of cyanocobalamin for certain gene variants).
  VenaZiel uses such modern genetic analyses to create a personalized micronutrient plan that takes genetic differences into account. 
• Other special tests: Depending on requirements, whole blood mineral analyses (e.g. for magnesium, which is more accurately measured intracellularly), hair mineral analyses (to see heavy metal loads and trace elements over a longer period of time) or stool and intestinal flora analyses (for intestinal health) can also be carried out.
  Even oxidative stress can be measured (for example, via the value 8-oxo-guanine as a marker for DNA oxidation, or the glutathione level). In some cases, the vitamin status is also determined directly in the cells (e.g. in lymphocytes), which can provide a more accurate picture of the supply situation than serum values.

Why this effort? Because only with thorough diagnostics is a truly tailor-made therapy possible. “Supplementation of micronutrients should be carried out on the basis of a micronutrient analysis. This is the only way to find out which micronutrients are actually lacking and should be specifically supplemented.”, advises a specialist medical center.

In practice, it turns out that if you simply take multivitamins on suspicion, it can easily lead to under- or overdoses of individual substances. With individual analysis, on the other hand, it can be determined, for example, that a patient only lacks vitamin D and perhaps zinc and magnesium, while everything else is okay – so he gets exactly these prescribed in the right amounts instead of applying a scattergun approach.

VenaZiel as a provider starts right here: Precise laboratory diagnostics and innovative procedures (as we will see in the next section) are used to create individual profiles.

The result is a micronutrient profile that represents the fingerprint of your nutrient health, so to speak. On the basis of this, the therapist can develop a personalized vital substance plan that may include dietary changes, high-quality dietary supplements in specific dosages and, if necessary, infusions.

Such personalized vital substance analysis is ultimately the key to the effectiveness of orthomolecular medicine – it separates the evidence-based use of micronutrients from mere vitamin pill guessing.

And another advantage: You can later check whether the values have improved by means of follow-up examinations and adjust the dose accordingly (or discontinue what is superfluous). This is precision medicine in the nutrient sector.

 

VenaZiel: Laboratory diagnostics, MRI and genetic analysis for personalized therapy

VenaZiel is a provider that combines orthomolecular medicine with state-of-the-art diagnostics and provides individual care for patients. But what makes VenaZiel special and how does such a treatment work?

First, VenaZiel relies on comprehensive laboratory diagnostics. As described above, blood tests are carried out in cooperation with specialized laboratories in order to determine your micronutrient profile precisely. All relevant vitamins, minerals, trace elements as well as inflammation and metabolic markers are recorded.

In addition, VenaZiel offers advanced diagnostic methods: These include MRI examinations (magnetic resonance imaging) and gene analyses. MRI is used, for example, as part of check-up programs – a high-resolution body scan can make hidden foci of inflammation, organ changes or circulatory disorders visible, which provide indications of nutrient deficiencies or requirements.

An example: In MRI, early signs of osteoporosis can be detected, which could indicate vitamin D and K2 deficiency, or fatty liver changes that are related to choline or omega-3 status. This imaging diagnostics thus complements the laboratory in order to draw a holistic picture of the patient.

The gene analysis at VenaZiel is used to enable personalized recommendations. Based on your genetic profile, the experts can recognize whether you utilize certain vital substances less well, for example (as in the MTHFR example for folic acid), or whether you have a higher risk of oxidative stress or inflammation.

Genetic predispositions for certain diseases are also checked, for example whether you have a variant that makes vitamin D receptors less efficient – then you will specifically pay attention to a good vitamin D level. VenaZiel integrates such findings into the therapy plan so that you receive the right nutrients in the right form.

After the diagnostics, a personalized micronutrient consultation takes place at VenaZiel. This means that you will be explained in detail which values are outside the norm and why.

Based on this, the team – consisting of experienced doctors and nutritional medicine specialists – creates a tailor-made vital substance plan. This plan can include dietary recommendations (e.g. integration of certain vitamin-rich foods), targeted dietary supplements in high-quality quality, and infusion therapies in the case of stronger deficits or needs.

In some cases, for example, highly dosed vitamin C infusions or multivitamin-mineral infusions are offered in order to quickly replenish the stores. Important: Everything happens without purely chemical drugs, but with natural, endogenous substances, which makes the concept so gentle and has few side effects.

Another advantage is the interdisciplinary approach: VenaZiel combines orthomolecular medicine with other medical disciplines. Since VenaZiel was originally known as a vein center, specialists for vascular health are active there – so vascular diagnostics (e.g. using MRI angiography) can be linked to vital substance analysis.

If, for example, calcifications in arteries are visible in the MRI, in addition to the usual measures, one will also check whether vitamin K2, vitamin D, magnesium are sufficiently available, as these also influence the calcification processes. Likewise, a holistic preventive examination at VenaZiel can uncover many “silent” construction sites in the body thanks to MRI – be it small inflammations, incipient degenerations or organ health.

The orthomolecular experts there can then intervene preventively before a slight weakness turns into a serious illness.

In short, VenaZiel acts as a competent partner on the path to better health through micronutrients. The approach is always scientifically substantiated and not esoteric: Modern technology such as MRI and genetic analysis meets evidence-based nutrient medicine.

This enables VenaZiel to advise its patients in a well-founded manner without recommending therapies at random. In this way, orthomolecular medicine is professionalized and individualized – which benefits both the patient’s well-being and confidence in this approach.

Note: Despite all these possibilities, orthomolecular medicine remains a supplement and prevention. VenaZiel attaches importance to working together with your family doctor or specialist. Especially in the case of serious illnesses, vital substance therapies are used in consultation with conventional treatment in order to achieve an optimal overall result.