Orthomolecular medicine: basics, effects, applications

Orthomolecular medicine makes exclusive use of these substances that are produced naturally in the body or derived from food and aims to compensate for deficiencies and restore the body’s biochemical balance. In layman’s terms: our cells should receive all the building blocks they need in optimal quantities in order to remain healthy and efficient.

Great importance is attached to a scientifically sound basis. Numerous vital substances are essential – the human body needs over 100 different micronutrients for the healthy functioning of all organs.

A lack of these substances can lead to a variety of problems. This is precisely where orthomolecular medicine comes in: Micronutrients are used as therapeutic agents, sometimes in high doses, to compensate for deficiencies and support the body’s self-healing powers.

However, it is important that this is done on an individual basis, as each person has their own requirements, depending on their diet, age, state of health and even genetic factors.

In this article you will get a comprehensive overview of the basics of orthomolecular medicine, the role of important nutrients, their significance for the immune system, cell protection, energy, anti-inflammation and hormone balance, as well as the diverse areas of application – from anti-ageing to support for chronic fatigue.

You will also find out why an individual vital substance analysis (e.g. through blood and genetic analysis) is so important and how the provider VenaZiel puts this natural approach into practice with modern diagnostics (incl. MRI and genetic analysis) and personalized advice.

Vitamins, minerals, trace elements & co.: the building blocks of orthomolecular medicine

Micronutrients are the central players in orthomolecular medicine. These primarily include vitamins and minerals, but also trace elements, amino acids, essential fatty acids and secondary plant substances such as antioxidants.

In contrast to macronutrients (carbohydrates, protein, fat), which provide the body with energy, micronutrients are involved in countless biochemical processes in the body – often as cofactors of enzymes or as structural components of cells and hormones. Here is an overview of the most important micronutrient groups and their role:

• Vitamins – vital all-rounders: Vitamins are organic compounds that the body needs for numerous functions. A distinction is made between fat-soluble vitamins (A, D, E, K) and water-soluble vitamins (C and the B vitamins). They are involved in growth, the immune system, metabolism, the nervous system and many other processes.
  Some examples: Vitamin A supports vision and the immune system (it used to be called the “anti-infectious vitamin” due to its importance for the immune system), vitamin C acts as an important antioxidant and strengthens the immune system, the B vitamins (B1, B2, B3, B5, B6, B7/biotin, B9/folic acid, B12) play central roles in energy metabolism, blood formation and nerve function. As vitamins, with the exception of vitamin D, cannot be produced by the body itself, they must be supplied regularly through food (or supplements).  
• Minerals and trace elements – small amounts, big effect: Minerals (such as calcium, magnesium, potassium) and trace elements (such as iron, zinc, selenium, copper, iodine) are inorganic nutrients that are essential for the body. Minerals are needed in somewhat larger quantities – e.g. calcium for bones and teeth, magnesium for muscle function and the heart and as an anti-stress mineral.
  Trace elements are only needed in tiny amounts, but are nevertheless critical: iron is needed for the formation of red blood cells and oxygen transport, zinc controls hundreds of enzyme reactions and supports wound healing as well as the immune system and hormone production, selenium is part of important antioxidant enzymes and is essential for thyroid function.
  An imbalance – be it a deficiency or an excess – can have a significant impact on health. Orthomolecular therefore focuses on keeping these micronutrients in the optimum range.  
• Amino acids – building blocks of proteins and more: Amino acids are the basic building blocks of proteins. Some amino acids are essential, i.e. they must be taken in with food (e.g. leucine, lysine, tryptophan), others can be produced by the body itself.
  In addition to their function as protein components, many amino acids have specific effects: Tryptophan is a precursor of the happiness hormone serotonin and can therefore influence mood and sleep, glutamine serves the cells of the intestine and immune system as a preferred source of energy, arginine promotes blood circulation (precursor of nitric oxide) and supports immune function, glycine is involved in detoxification.
  Amino acids are also used specifically in orthomolecular therapy, for example to support brain metabolism or the muscles if there are corresponding deficits or increased requirements.
  Protein enzymes such as coenzyme Q10 – strictly speaking a vitaminoid – or carnitine (transport molecule for fatty acids into the mitochondria) also fall into this extended area of vital substances, as they are important for cell energy and metabolism. 
• Antioxidants – cell protection against free radicals: Antioxidants are substances that can reduce oxidative stress by neutralizing harmful free radicals.
  Many vitamins and trace elements act as antioxidants: e.g. vitamin C in aqueous areas of the body (blood, cell plasma) and vitamin E in fatty structures such as cell membranes.
  Selenium and zinc are components of antioxidant enzyme systems (such as glutathione peroxidase and superoxide dismutase). Secondary plant substances (polyphenols, carotenoids such as beta-carotene, flavonoids) are also included. Antioxidants protect cells from ageing processes and environmental stress and therefore play an important role in disease prevention and anti-ageing. More on this in the section on cell protection below.

Tip: A balanced diet with plenty of fresh fruit, vegetables, nuts, whole grains and fish provides an abundance of these micronutrients. Orthomolecular medicine also aims to increase the intake in a targeted manner in the event of specific additional requirements or illnesses.

In the next step, we look at how exactly these vital substances work in the body – particularly in relation to immune defense, cell health, energy, inflammatory processes and the hormone system. These fields of action illustrate why orthomolecular medicine is relevant for many aspects of health.

Immune system: vitamins and minerals as a protective shield

A well-functioning immune system depends largely on an adequate supply of micronutrients. In fact, there is hardly a nutrient that does not play some kind of role in immune defense. Various vitamins and minerals act as fuel and regulators of our immune system: they support the formation and activity of immune cells, the production of antibodies and communication via messenger substances (cytokines).

Vitamin C, vitamin D, vitamin A, the B vitamins (B6, B12, folate) as well as zinc, selenium, iron and copper are particularly important for the immune system. All of these micronutrients contribute to the normal function of the immune system.

Vitamin A, for example, is also known as the “anti-infectious vitamin” due to its protective effect on the skin and mucous membranes – our first barrier against germs. Vitamin D acts as an important immune regulator molecule: It supports the maturation of immune cells and slows down excessive inflammatory reactions, which is relevant in autoimmune diseases, for example. According to studies, a sufficient vitamin D level reduces susceptibility to respiratory infections and can alleviate the course and severity of infections.

Vitamin C is essential for the function of white blood cells; the body’s consumption of this vitamin increases sharply during infections. It has been shown that vitamin C can attenuate and shorten cold symptoms. Vitamin C also promotes the breakdown of histamine, a substance that plays a role in allergies, and can therefore alleviate allergic reactions.

B vitamins are also immune-relevant: B6, B12 and folate are required for the formation and multiplication of immune cells; a deficiency can impair antibody production and inflammation defense. Zinc is a trace element that supports almost all components of the immune system – from the skin barrier to the production of lymphocytes.

A zinc deficiency often leads to increased susceptibility to infections and poorer wound healing. Selenium protects immune cells from oxidative damage and is important for regulating inflammation. Iron, in turn, is required by immune cells for their division; at the same time, a good iron metabolism deprives pathogens of this equally important element.

For a strong immune system, it therefore makes sense to ensure an adequate supply of micronutrients. In orthomolecular medicine, the individual status of these nutrients is often checked by blood test in order to specifically replenish what is missing.

This can be particularly useful for people with frequent infections, immune deficiencies, allergies or autoimmune diseases. Important: Targeted supplementation after diagnosis helps to supplement exactly those vital substances that are actually needed – this provides optimum support for the immune system without placing unnecessary strain on the body.

Cell protection: antioxidants against free radicals

Our cells are attacked daily by so-called free radicals – aggressive oxygen compounds that are produced, for example, during normal metabolism, stress, smoking, UV radiation or environmental pollution.

When these radicals get out of hand, oxidative stress occurs, which can damage cells and promote ageing processes and chronic diseases. Antioxidants are nature’s answer to this problem. They render free radicals harmless and thus protect cells, proteins, lipids and even DNA from damage.

Important antioxidants in the body are vitamin C, vitamin E, beta-carotene/vitamin A, as well as the trace elements zinc, selenium and copper, which are components of antioxidant enzymes. Vitamin C works in the aqueous environment of the cell and in the blood as a radical scavenger – it intercepts radicals, for example, before they can damage the cell membrane or other structures.

Vitamin E is located directly in the cell membranes and protects the fat layers from oxidation. A vitamin E deficiency is associated with increased susceptibility to infections and inflammation, while a good supply of vitamin E has been shown to reduce the frequency of respiratory tract infections in older people, for example.

Beta-carotene (provitamin A) and other carotenoids such as lutein and lycopene protect sensitive tissues (e.g. the eyes or skin) from UV damage and oxidative stress. Selenium is essential for the enzyme glutathione peroxidase, which protects cell membranes from peroxide formation, and zinc and copper are part of superoxide dismutase, an enzyme that neutralizes dangerous superoxide radicals.

Antioxidants such as those found in fresh berries (rich in vitamin C and polyphenols) act as natural radical scavengers that protect cells from oxidative stress and counteract ageing processes. In addition to the vitamins and minerals mentioned, secondary plant substances also provide strong cell protection.

For example, berries, green tea, cocoa, turmeric, red grapes etc. are considered to be rich in polyphenols and flavonoids, which have an antioxidant and anti-inflammatory effect. This cell protection by antioxidants is not only important for anti-ageing (healthy skin, tissue protection, prevention of premature ageing), but also plays a role in the prevention of chronic diseases such as cardiovascular diseases, some types of cancer and neurodegenerative diseases.

Studies show, for example, that people with a higher intake of antioxidants have a lower risk of certain chronic diseases – although it must always be emphasized: Antioxidants are prevention aids, not miracle cures.

A well-balanced network of antioxidants in the body (including endogenous substances such as glutathione, coenzyme Q10 and enzymes) ensures that free radicals are kept in check.

In orthomolecular medicine, antioxidants are often used in high doses to counteract increased oxidative stress – for example, high doses of vitamin C (sometimes as an infusion) to support the immune system or vitamin E for inflammatory diseases.

The right dosage and combination is always important: too much of a single antioxidant can also have a pro-oxidant effect if it is overdosed in isolation. It is therefore better to use a mix of different antioxidants, adapted to individual needs, to ensure optimum cell protection.

Energy production: micronutrients for more energy and performance

Do you often feel tired or drained? Then it might be worth taking a look at micronutrients, because our energy production in the cells – mainly in the mitochondria, the “power plants” of the cells – depends largely on vitamins and minerals.

The conversion of food into ATP (adenosine triphosphate), the universal energy carrier, requires a whole range of cofactors. B vitamins play a central role here: all B vitamins except folic acid are indispensable in at least one, usually several, steps of cellular energy production.

Vitamin B1 (thiamine) is needed for the breakdown of carbohydrates and entry into the citrate cycle – a B1 deficiency quickly leads to tiredness and poor concentration. Vitamin B2 (riboflavin) and B3 (niacin) are components of the coenzymes FAD and NAD, which transport electrons in the respiratory chain of the mitochondria and thus enable ATP production.

Vitamin B5 (pantothenic acid) is a component of coenzyme A, also essential for energy metabolism, and vitamin B6 is needed by the body to convert amino acids for energy production. Vitamin B12 and folic acid, on the other hand, are important for blood formation (oxygen transport) and for the nerves – a deficiency manifests itself in fatigue, weakness and neurological disorders, among other things.

In addition to the B vitamins, minerals such as magnesium and iron are crucial: magnesium is involved in hundreds of enzymatic reactions and is essential for the stabilization and use of ATP. Iron is needed to transport oxygen in the blood (via haemoglobin) and is also used by the mitochondria to generate energy.

An iron deficiency can therefore lead to a lack of energy and reduced performance (e.g. in the case of anemia). Zinc and selenium indirectly support the energy supply, among other things through their role in thyroid functions (thyroid hormones regulate the basal metabolic rate) and in protecting the mitochondria from oxidative stress.

Coenzymes and other vital substances are particularly exciting: for example, coenzyme Q10 is a central component of the mitochondrial respiratory chain – it acts as an electron transmitter. A deficiency of Q10 (which can occur with increasing age or through the use of some medications such as statins) is associated with muscle weakness and fatigue.

Carnitine is important for transporting fatty acids into the mitochondria, where they are burned; without sufficient carnitine, fat remains unused as an energy reserve. Lipoic acid, a vitamin-like substance, also plays a role in energy metabolism and has an antioxidant effect in the mitochondria.

You can see that without micronutrients there is no energy. Anyone who suffers from constant fatigue should not only think about sleep and stress, but also about their supply of vital nutrients. Chronic fatigue can be caused by deficiencies in B12, B1, B6, iron, vitamin D or magnesium, for example.

Under prolonged stress, the consumption of these vital substances even increases, which can lead to a vicious circle. An optimal supply, on the other hand, allows the “energy power plants” to work efficiently. One health platform recommends: “To produce sufficient energy, the mitochondria need vitamins B1, B2, B3, B5 and B6 as well as trace elements such as iron, zinc and selenium – as well as coenzymes such as Q10.” .

It is precisely these substances that are used in orthomolecular medicine to improve cellular energy production. In many cases, patients with chronic fatigue or burnout report that individually tailored micronutrient therapy has significantly increased their energy and performance. (More on this later in the application areas).

To summarize: Micronutrients are the sparkplugs in the engine of our metabolism. From the food chain to ATP synthesis – nothing works without vitamins and co. Orthomolecular medicine ensures that all these little helpers are available in sufficient quantities so that we feel vital and full of energy.

Inflammation inhibition: nutrients as natural inflammation modulators

Chronic inflammation is considered a smouldering danger in the body – it is associated with numerous diseases of civilization (from joint problems and cardiovascular disorders to diabetes and neurodegenerative diseases).

Interestingly, many micronutrients can have anti-inflammatory effects by interfering with the immune response and the production of inflammatory messengers.

One prominent example is vitamin D: this “sun vitamin” regulates the release of cytokines (messenger substances of the immune system) and can dampen excessive inflammatory reactions. Studies have shown that patients with sufficient vitamin D levels often have milder courses of inflammatory diseases than those with vitamin D deficiency. Vitamin D can also help to rebalance the immune response in autoimmune diseases (where the immune system is overactive and “misdirected”).

Vitamin E not only acts as an antioxidant, but also has a direct anti-inflammatory effect, for example by inhibiting the release of pro-inflammatory molecules. Vitamin E has been successfully used as an adjunctive measure in arthritis, allergies and skin inflammation to alleviate the symptoms.

Omega-3 fatty acids (EPA and DHA, e.g. from fish oil or algae oil) also play a major role in inhibiting inflammation. They compete with omega-6 fatty acids in the body and lead to the formation of eicosanoids (tissue hormones) that dissolve rather than promote inflammation.

Numerous studies have shown that omega-3 supplementation can reduce chronic inflammation markers and alleviate joint pain in rheumatism, for example. In orthomolecular medicine, omega-3 fatty acids are often given together with antioxidants because inflammation and oxidative stress go hand in hand.

Herbal anti-inflammatories are also part of the repertoire: curcumin (from turmeric), resveratrol (from red grapes), ginger extracts or boswellic acids (frankincense) are natural substances with a strong anti-inflammatory effect that can be used as orthomolecular supplements.

Although these are not “classic” vitamins or minerals, they are among the vital substances that orthomolecular medicine values to support the body in regulating inflammation.

Last but not least is magnesium: As an anti-stress mineral, it helps to calm the nervous system and regulate the stress hormone axis. Prolonged stress is known to lead to an increased release of cortisol, which in high doses has an immunosuppressive and bone-breaking effect and tends to promote inflammation.

Magnesium can mitigate this stress-inflammation spiral, among other things by limiting the release of histamine (which dampens allergic inflammatory reactions). The body also needs sufficient zinc and vitamin C to resolve inflammatory processes and repair tissue.

All in all, it can be said that micronutrients act covertly as small anti-inflammatory agents. They strengthen the body’s own mechanisms to limit inflammation and regenerate damaged tissue.

This is why orthomolecular medicine – especially in the case of chronic inflammatory diseases such as arthritis, intestinal inflammation, skin eczema or even silent inflammation (e.g. metabolic syndrome) – relies specifically on these natural helpers. The advantage is that, unlike medication, vitamins, minerals and the like are physiological substances and usually have fewer side effects, while at the same time addressing the causes (i.e. compensating for nutrient imbalances and restoring normal immune control).

Of course, this should be done alongside and in consultation with therapists, especially in the case of serious illnesses, but experience shows that orthomolecular strategies can have a beneficial effect on inflammatory processes.

Hormone balance: micronutrients as silent helpers of the hormone system

Our hormone system is a finely tuned network of messenger substances that regulates numerous functions – from metabolism and growth to mood and reproduction. It is easy to overlook the fact that micronutrients are also required for the formation and function of hormones. In fact, vitamins and minerals are integral components of many hormones or the enzymes that produce and activate hormones.

A classic example is the thyroid gland: iodine is needed to produce the thyroid hormones T3 and T4 – an iodine deficiency can lead to hypothyroidism. At the same time, the thyroid gland needs selenium, as important enzymes (deiodases) are selenium-dependent in order to convert the storage hormone T4 into the active T3. Without sufficient selenium and iodine, the thyroid hormone balance becomes unbalanced, which can result in a lack of energy, weight gain or sensitivity to cold.

Vitamin D itself is actually more of a hormone than a vitamin – in addition to the calcium balance, it also regulates many gene regulatory processes and influences, for example, the insulin secretion of the pancreas and testosterone levels. An optimal vitamin D status is associated with balanced hormone levels and better fertility, while a deficiency can derail the stress hormone cortisol, for example.

Micronutrients also play a role in the sex hormones: zinc is important for the formation of testosterone and influences the receptor sensitivity of oestrogen. A zinc deficiency can therefore be associated with low testosterone or potency disorders, while sufficient zinc intake improves fertility (sperm quality) in men.

Vitamin B6 is a cofactor in the synthesis of various neurotransmitters and hormones – for example, it helps in the formation of serotonin and dopamine, which indirectly influence the hormone balance (e.g. stress and sex hormones). B6 also contributes to the regulation of oestrogen, which is why it is used in natural PMS therapy.

Pantothenic acid (vitamin B5) is necessary for the production of steroid hormones such as cortisol, testosterone and estrogen – it forms part of coenzyme A, which is involved in the synthesis of these hormones.

Not forgetting magnesium and vitamin C: both are required by the adrenal glands to produce stress hormones (adrenaline, noradrenaline) and break them down again at the same time. Chronic stress can lead to “adrenal insufficiency”, in which magnesium and vitamin C levels are often depleted.

The influence of amino acids is also interesting: serotonin (happiness hormone) is produced from the amino acid tryptophan and from this melatonin (sleep hormone) – this process in turn requires micronutrients such as B6, B3, zinc and magnesium as cofactors.

The thyroid hormones and the adrenal hormones adrenaline and noradrenaline are formed from phenylalanine/tyrosine; several vitamins are also involved here. As you can see, hormone production resembles a complicated machine in which vitamins (especially B vitamins), minerals and amino acids are involved as cogwheels.

For a balanced hormone balance it is therefore not only important to eat enough calories, but also the quality of the nutrient intake.

Orthomolecular medicine can provide support for hormonal complaints – be it thyroid problems, stress hormone imbalances (burnout/adrenal fatigue), fertility problems or menopausal symptoms – by specifically administering the vital substances that the hormonal system is lacking. For example, an individually tailored administration of iodine, selenium, zinc and vitamins can help the thyroid metabolism, or magnesium and B vitamins can normalize cortisol regulation in cases of stress-related exhaustion.

Studies and experience show that patients are often less susceptible to stress and hormonal fluctuations after orthomolecular support and benefit, for example, from sleep, energy and mood.

To summarize: Micronutrients are the secret helpers of the hormone system. They ensure that hormones are correctly produced, activated, regulated and broken down. An individual vital substance analysis (see next section) can provide information on whether there are deficiencies that should be compensated for – for a harmonious “hormone balance” in a natural way.

Areas of application of orthomolecular medicine: from anti-ageing to chronic diseases

Orthomolecular medicine is used in many areas, whether preventively for health care or therapeutically to treat a wide range of complaints. Here are some of the most important areas of application and examples of how micronutrients can help:

• Anti-aging and prevention: One of the major trends is the use of vital substances in anti-ageing. Antioxidant vitamins (C, E, beta-carotene), coenzyme Q10, omega-3 fatty acids and trace elements such as selenium or zinc are said to slow down the ageing process at a cellular level by reducing oxidative stress and preventing inflammation. This manifests itself, for example, in healthier skin (collagen formation through vitamin C, skin protection through vitamin E), better immune function in old age and protection against degenerative processes.
  Prevention in general – i.e. the prevention of diseases – is also a core concern: Micronutrients can help to minimize risk factors (such as B vitamins plus omega-3 to lower homocysteine levels and inflammation markers, which reduces cardiovascular risks).
  Important to emphasize: Orthomolecular medicine is not a fountain of youth pill, but a building block of a health-conscious lifestyle that can promote a high level of vitality into old age.
  Those who consciously replenish their micronutrient stores from around 40+ can often observe that typical age-related complaints (tiredness, lack of concentration, susceptibility to infections) are reduced.
• Chronic exhaustion and burnout: Orthomolecular therapy has proven to be very helpful in cases of constant tiredness, burnout or chronic fatigue syndrome (CFS). Under constant stress, the stores of B vitamins, magnesium, vitamin C and other vital substances are rapidly depleted.
  At the same time, stress can disrupt digestion and the absorption of nutrients. The result is a vicious circle of exhaustion and vital substance deficiencies. High doses of B vitamins (B complex), magnesium and possibly adaptogens (such as rhodiola or ashwagandha, which alleviate stress reactions) are used here.
  Studies report that targeted micronutrient therapy based on laboratory results can sustainably improve burnout syndrome. In particular, energy production in the mitochondria is promoted (e.g. by coenzyme Q10, acetyl-L-carnitine, nicotinamide riboside etc.), which often leads to a noticeable improvement in performance in cases of chronic fatigue.
  Patients with burnout often feel more resilient more quickly with orthomolecular support, sleep better and are better able to compensate for stress. Individual diagnostics are important here (see below) to determine which vital substances are missing in a specific case – be it vitamin D in winter, iron in women with fatigue or B12 in vegans.  
• Cardiovascular health: The health of the heart and blood vessels can be positively influenced by micronutrients. Omega-3, for example, has been shown to help lower triglyceride levels, regulate blood pressure and have an anti-inflammatory effect – good for the heart and circulation.
  Magnesium relaxes the vascular muscles, can prevent cardiac arrhythmia and moderately lowers blood pressure. Coenzyme Q10 improves the energy supply to the heart muscle and is used to support heart failure (also because Q10 is reduced by statins).
  Another topic is homocysteine: elevated homocysteine levels in the blood are considered a risk factor for arteriosclerosis. A sufficient supply of vitamins B6, B12 and folic acid can reduce homocysteine – orthomolecular medicine uses this to prevent heart attacks and strokes. Antioxidants (vitamins C, E, selenium) also protect the inner walls of blood vessels from oxidative damage (e.g. from oxidized LDL cholesterol).
  All in all, a personalized supply of vital substances can help to keep high blood pressure, high blood lipids or vascular calcification in check – of course always in combination with lifestyle measures such as a healthy diet, exercise and stopping smoking. 
• Gastrointestinal and digestion: Digestive problems, irritable bowel syndrome, chronic intestinal inflammation (Crohn’s disease, ulcerative colitis) or simply damaged intestinal flora can impair the absorption of nutrients. Here it is first important to compensate for deficiencies due to poor absorption (such as B12 in the case of absorption disorders in the small intestine, or iron/zinc in the case of chronic inflammation).
  Orthomolecular medicine also supports intestinal health itself: Glutamine, for example, is an amino acid that can regenerate and seal the intestinal mucosa (keyword: leaky gut prevention).
  Omega-3 fatty acids and vitamin D have an anti-inflammatory effect in the gut in IBD (inflammatory bowel disease). Probiotics and prebiotic fiber (not micronutrients in the classic sense, but nevertheless important nutritional components) are also often combined with orthomolecular concepts to improve the intestinal environment.
  Digestive enzymes, bitter substances or magnesium (against constipation) can also be used. Last but not least: The intestinal immune system (70% of immune cells are located in the intestine) benefits from zinc and vitamin A, which keep the mucous membranes intact. Orthomolecular therapy thus helps to restore balance, close nutrient gaps and calm inflammation in patients with irritable bowel syndrome, for example – often with the effect of reducing abdominal pain, flatulence or intolerances.  
• Skin, hair and connective tissue: As the largest organ, the skin reacts very sensitively to the supply of nutrients. Many skin problems can be improved by orthomolecular measures. Acne, for example, is often associated with zinc deficiency – zinc reduces sebum production and inflammation in the skin.
  Biotin (vitamin B7) and vitamin B2 are important for a healthy skin barrier; their deficiencies can lead to flaky skin or cracks. Vitamin C, collagen peptides, silicon, sulphur (MSM) strengthen the connective tissue and can slow down cellulite or wrinkles by promoting collagen synthesis. Antioxidants protect the skin from UV damage and ageing – beta-carotene, for example, acts as an internal sunscreen to a certain extent.
  Hair loss and brittle nails are other areas: Biotin, zinc, selenium, iron and amino acids such as cysteine, which strengthen the keratin structure, often come into play here. In the case of skin eczema or neurodermatitis, supplementation with omega-3, vitamin D and probiotics has been shown in studies to be helpful in reducing the skin’s susceptibility to inflammation.
  Orthomolecular medicine therefore also offers approaches in the area of beauty and healthy appearance that work from within – without any chemicals, but with nutrients that make the skin glow and strengthen the hair. 
• Neurological complaints and mental health: The brain and nerves are dependent on micronutrients. In neurological diseases such as polyneuropathies (nerve damage), for example, a vitamin B12 deficiency or B1 deficiency is often found – supplementation can improve numbness and nerve dysfunction.
  Magnesium and vitamin B2 can reduce migraine attacks as they are involved in neuromuscular stimulus conduction and energy supply to brain cells. Vitamin D plays a role in neurodegenerative diseases: Deficiency may increase the risk of multiple sclerosis or Parkinson’s disease, while good supply could slow progression (research on this is ongoing).
  In the area of mental health, we know the classic correlations: low folic acid and B12 levels can contribute to depression (homocysteine increases, serotonin production decreases), an omega-3 deficiency is associated with an increased risk of depression and anxiety, magnesium has a calming effect on anxiety and sleep disorders.
  Orthomolecular approaches therefore provide for the concomitant administration of high doses of B vitamins, magnesium, omega-3 and amino acids (such as tryptophan or tyrosine) to optimize the biochemical environment in the brain in cases of depression, for example. Dementia prevention is also an issue: antioxidants such as vitamins E and C, omega-3 and B vitamins are being investigated to see whether they can slow down cognitive decline.
  While orthomolecular medicine cannot of course cure neurological diseases, it can provide a building block to optimally nourish the nerves and brain and thus alleviate symptoms or delay their progression.

To summarize: orthomolecular medicine is used in almost all areas where something is “missing” or out of balance in the body.
It serves to prevent illness by creating optimal conditions for health and to support therapies by giving the body the necessary resources to help itself better. It is always important to personalize the measures – which leads us to the next point: individual diagnostics.

Individual vital substance analysis: Why diagnostics are so important

Every person has a unique nutritional requirement and status. What one person lacks, another has in abundance. Orthomolecular medicine therefore places great importance on individual diagnostics before micronutrients are recommended or supplemented. An individual vital substance analysis can include several components:

• Blood tests: The gold standard is a comprehensive blood test to determine the status of various vitamins, minerals, trace elements and markers. This includes, for example, the measurement of 25-OH-vitamin D (storage form of vitamin D in the blood), vitamin B12 and holotranscobalamin (active B12), folic acid, iron/ferritin, magnesium, zinc, selenium, vitamin A, vitamin E, hs-CRP (inflammation marker), homocysteine (as an indication of B-vitamin deficiency) and many more.
  An amino acid profile can also be created in the blood or urine to see whether, for example, tryptophan, glutamine or other important amino acids are sufficiently present. These comprehensive micronutrient diagnostics show which nutrients are actually missing instead of blindly supplementing.
  Example: Fatigue can be caused by iron deficiency, B12 deficiency, vitamin D deficiency or an excess of calcium (which displaces magnesium) – the blood values provide clarity. 
• Genetic tests (genetic analysis): Genetics influences how we metabolize nutrients. Today there are nutrigenetic tests that examine, for example, whether you have genetic variants that influence the absorption or processing of certain vitamins.
  One well-known example is the MTHFR polymorphism, which makes folic acid utilization more difficult – people with this gene variant often need activated folate (5-MTHF) instead of normal folic acid. Other tests look at lactose intolerance genes, gluten intolerance markers or genes that determine the ability to detoxify (glutathione system).
  A genetic analysis can show where congenital weaknesses lie so that targeted countermeasures can be taken – for example by increasing the intake of certain vitamins or using special forms (e.g. methyl-B12 instead of cyanocobalamin for certain gene variants).
  VenaZiel uses such modern genetic analyses to create a personalized micronutrient plan that takes genetic differences into account. 
• Other special tests: Depending on requirements, whole blood mineral analyses (e.g. for magnesium, which is more accurately measured intracellularly), hair mineral analyses (to see heavy metal loads and trace elements over a longer period of time) or stool and intestinal flora analyses (for intestinal health) can also be carried out.
  Even oxidative stress can be measured (e.g. via the value 8-oxo-guanine as a marker for DNA oxidation, or the glutathione level). In some cases, the vitamin status is also determined directly in the cells (e.g. in lymphocytes), which can provide a more accurate picture of the supply situation than serum values.

Why all this effort? Because a truly customized therapy is only possible with thorough diagnostics. “Micronutrient supplementation should be based on a micronutrient analysis. This is the only way to find out which micronutrients are actually missing and should be specifically supplemented,” advises a specialist medical center.

In practice, it has been shown that simply taking multivitamins on suspicion can easily lead to under- or overdoses of individual substances. With individual analysis, on the other hand, it is possible to determine, for example, that a patient is only lacking vitamin D and perhaps zinc and magnesium, while everything else is okay – so they are prescribed exactly the right amounts instead of applying a watering can principle.

VenaZiel as a provider starts right here: Precise laboratory diagnostics and innovative procedures (as we will see in the next section) are used to create individual profiles.

The result is a micronutrient profile, which is effectively the fingerprint of your nutritional health. Based on this, the therapist can draw up a personalized vital substance plan, which may include dietary changes, high-quality nutritional supplements in specific dosages and, if necessary, infusions.

Such personalized vital substance analysis is ultimately the key to the effectiveness of orthomolecular medicine – it separates the evidence-based use of micronutrients from mere vitamin pill guessing.

And another advantage: Follow-up examinations can be carried out later to check whether the values have improved and the dose can be adjusted accordingly (or superfluous substances can be discontinued). This is precision medicine in the area of nutrients.

VenaZiel: Laboratory diagnostics, MRI and genetic analysis for personalized therapy

VenaZiel is a provider that combines orthomolecular medicine with state-of-the-art diagnostics and provides patients with individualized care. But what makes VenaZiel special and how does the treatment work?

First of all, VenaZiel relies on comprehensive laboratory diagnostics. As described above, blood analyses are carried out in collaboration with specialized laboratories to precisely determine your micronutrient profile. All relevant vitamins, minerals, trace elements and inflammatory and metabolic markers are recorded.

In addition, VenaZiel offers advanced diagnostic methods: These include MRI examinations (magnetic resonance imaging) and genetic analyses. MRI is used, for example, as part of check-up programs – a high-resolution body scan can reveal hidden areas of inflammation, organ changes or circulatory disorders that indicate nutritional deficiencies or requirements.

For example: MRI can reveal early signs of osteoporosis, which could indicate vitamin D and K2 deficiency, or fatty liver changes related to choline or omega-3 status. These imaging diagnostics therefore complement the laboratory in order to paint a holistic picture of the patient.

The genetic analysis at VenaZiel is used to provide personalized recommendations. Based on your genetic profile, the experts can identify whether you are less able to utilize certain vital substances (as in the MTHFR example for folic acid) or whether you have a higher risk of oxidative stress or inflammation.

Genetic predispositions to certain diseases are also tested, such as whether you have a variant that makes vitamin D receptors less efficient – in which case you will be specifically targeted for a good vitamin D level. VenaZiel integrates such findings into the treatment plan so that you receive the right nutrients in the right form.

After the diagnosis, a personalized micronutrient consultation takes place at VenaZiel. This means that you will receive a detailed explanation of which values are outside the norm and why.

Based on this, the team – consisting of experienced doctors and nutritionists – creates a customized vital substance plan. This plan can include dietary recommendations (e.g. integration of certain vitamin-rich foods), targeted high-quality nutritional supplements and, in the case of severe deficiencies or need, infusion therapies.

In some cases, for example, high-dose vitamin C infusions or multivitamin-mineral infusions are offered to quickly replenish the body’s stores. Important: Everything is done without purely chemical medication, but with natural, endogenous substances, which makes the concept so gentle and low in side effects.

Another plus point is the interdisciplinary approach: VenaZiel combines orthomolecular medicine with other medical specialties. As VenaZiel was originally known as a vein center, specialists in vascular health work there – so vascular diagnostics (e.g. using MRI angiography) can be combined with vital substance analysis.

If, for example, calcium deposits in arteries are visible in the MRI, in addition to the usual measures, it will also be checked whether vitamin K2, vitamin D and magnesium are sufficiently present, as these also influence the calcification processes. A holistic preventive examination at VenaZiel can also reveal many “silent” construction sites in the body thanks to MRI – be it small inflammations, incipient degeneration or organ health.

The orthomolecular experts there can then intervene preventively before a slight weakness turns into a serious illness.

In short, VenaZiel acts as a competent partner on the path to better health through micronutrients. The approach is always scientifically underpinned and not esoteric: modern technology such as MRI and genetic analysis meets evidence-based nutrient medicine.

This allows VenaZiel to provide its patients with sound advice without recommending therapies in the blue. Orthomolecular medicine is thus professionalized and individualized – which benefits both patient well-being and trust in this approach.

Note: Despite all these possibilities, orthomolecular medicine remains a supplement and prevention. VenaZiel emphasizes the importance of working together with your family doctor or specialist. Especially in the case of serious illnesses, vital substance therapies are used in consultation with conventional treatment in order to achieve an optimal overall result.